Publications Scientifiques


A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. Lacasse V, Beaudoin S, Jean S, Leyton JV. Mol Ther Methods Clin Dev. 2020 Sep 1

Oncolytic vesicular stomatitis virus-based cellular vaccine improves triple-negative breast cancer outcome by enhancing natural killer and CD8+ T-cell functionality. Niavarani SR, Lawson C, Boudaud M, Simard C, Tai LH. J Immunother Cancer. 2020 Mar;8(1)

Elucidating the Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b. Zerif E, Khan FU, Raki AA, Lullier V, Gris D, Dupuis G, Amrani A. Int J Mol Sci. 2020 Sep 4;21(18)


Proteomic-based evaluation of nuclear transport of NLS-tagged trastuzumab-emtansine with enhanced cytotoxic potency Vincent Lacasse, Simon Beaudoin, Steve Jean, Jeffrey V. Leyton.

Spore Germination Requires Ferrichrome Biosynthesis and the Siderophore Transporter Str1 in Schizosaccharomyces pombe. Plante S, Labbé S. Genetics. 2019 Mar;211(3):893-911. doi: 10.1534/genetics.118.301843. Epub 2019 Jan 15. PMID: 30647069

Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period. Niavarani SR, Lawson C, Bakos O, Boudaud M, Batenchuk C, Rouleau S, Tai LH. BMC Cancer. 2019 Aug 20;19(1):823. doi: 10.1186/s12885-019-6045-y. PMID: 31429730

Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B. Hamel-Côté G, Lapointe F, Gendron D, Rola-Pleszczynski M, Stankova J. Cell Commun Signal. 2019 Mar 4;17(1):21. doi: 10.1186/s12964-019-0334-6. PMID: 30832675

Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D4-Induced CXCL8 Expression. Lapointe F, Turcotte S, Véronneau S, Rola-Pleszczynski M, Stankova J. J Pharmacol Exp Ther. 2019 May;369(2):270-281. doi: 10.1124/jpet.118.255422. PMID: 30867226

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D. PLoS Biol. 2019 Sep 16;17(9):e3000451 PMID: 31525189

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes. Mahmoud S, Gharagozloo M, Simard C, Amrani A, Gris D. Cells. 2019 Apr 30;8(5). pii: E400. doi: 10.3390/cells8050400. PMID: 31052241

Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2. Hamel-Côté G, Lapointe F, Véronneau S, Mayhue M, Rola-Pleszczynski M, Stankova J. Cell Biosci. 2019 Jun 25;9:51. doi: 10.1186/s13578-019-0316-9. eCollection 2019. PMID: 31289638

Analyses of rRNA gene chromatin in cell cycle arrested Saccharomyces cerevisiae cells. Paillé A, Charton R, Muguet A, Griesenbeck J, Smerdon MJ, Conconi A. Data Brief. 2019 May 31;25:104083. doi: 10.1016/j.dib.2019.104083. eCollection 2019 Aug. PMID: 31294051

In yeast cells arrested at the early S-phase by hydroxyurea, rRNA gene promoters and chromatin are poised for transcription while rRNA synthesis is compromised. Charton R, Muguet A, Griesenbeck J, Smerdon MJ, Conconi A. Mutat Res. 2019 May;815:20-29. PMID: 31063901


Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue. Dianati V, Navals P, Couture F, Desjardins R, Dame A, Kwiatkowska A, Day R, Dory YL. J Med Chem. 2018 Dec 27;61(24):11250-11260

Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines. Dianati V, Kwiatkowska A, Couture F, Desjardins R, Dory YL, Day R. J Med Chem. 2018 Sep 27;61(18):8457-8467. doi: 10.1021/acs.jmedchem.8b01144. Epub 2018 Sep 17. PMID: 30180568

The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis. Gharagozloo M, Mahmoud S, Simard C, Mahvelati TM, Amrani A, Gris D Cells. 2018; 7: pii: E119 PMID: 30150571

IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes. Boudaud M, Turcotte S, Stankova J, Rola-Pleszczynski M J Immunol. 2018; 201: 2787 PMID: 30242072

Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells. Guindi C, Cloutier A, Gaudreau S, Zerif E, McDonald PP, Tatsiy O, Asselin C, Dupuis G, Gris D, Amrani AA. Cells. 2018 Dec 7;7(12). pii: E256. doi: 10.3390/cells7120256. PMID: 30544623

Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer. Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F. Oncotarget. 2018 Jan 5;9(11):9885-9906. doi: 10.18632/oncotarget.24009. eCollection 2018 Feb 9. PMID: 29515778


Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury. Theus MH, Brickler T, Meza AL, Coutermarsh-Ott S, Hazy A, Gris D, Allen IC J Immunol. 2017; 199: 3547 PMID: 28993512

Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Paquette M, Vilera-Perez LG, Beaudoin S, Ekindi-Ndongo N, Boudreaut PL, Bonin MA, Battista MC, Bentourkia M, Lopez AF, Lecomte R, Marsault E, Guérin B, Sabbagh R, Leyton JV.Oncoimmunology. 2017; 19: 6: e1331195. PMID: 29123949

Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. Ear T, Tatsiy O, Allard FL, McDonald PP J Immunol Res. 2017; 2017: 4347121 PMID: 28512645

Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway.Hamel-Côté G, Gendron D, Rola-Pleszczynski M, Stankova J PLoS One. 2017; 12: e0180336 PMID: 28686728

Modular sub-monomeric cell-penetrating guanidine-rich peptoids – synthesis, assembly and biological evaluation. E. Marouseau, A. Neckebroeck, H. Larkin, A. Le Roux, L. Volkov, C. L. Lavoie and E. Marsault RSC Adv. 2017; 7: 6059

Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination. Plante S, Normant V, Ramos-Torres KM, Labbé SJ Biol Chem. 2017; 292: 11896 PMID: 28572514

Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, Gris D, Stankova J, Rola-Pleszczynski M, Mourad W, Dupuis G, Amrani A. J Autoimmun. 2017; 76: 63 PMID: 27634616

Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.Małuch I, Levesque C, Kwiatkowska A, Couture F, Ly K, Desjardins R, Neugebauer WA, Prahl A, Day R J Med Chem. 2017; 60: 2732 PMID: 28287731