Plateforme de cytométrie

20 (59) CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKS reveals a role in regulating nucleolar structures and composition. Frion J, Meller A, Marbach G, Lévesque D, Roucou X, Boisvert FM. PMED 37670689

19 (58) Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host–Guest Inclusion Complex with β-Cyclodextrin; Molecular Pharmaceutics 2023; P Navals, A Kwiatkowska, N Mekdad, F Couture, R Desjardins, R Day, YL Dory; PMED 37555521

1 (57) A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging; Ancel, S., Michaud, J., Sizzano, F., Tauzin, L., Oliveira, M., Migliavacca, E., ... & Bentzinger F.; Stuelsatz, P; . bioRxiv 2023

18 (56) Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development; Translational Research. 2023; Guindi C, Khan FU, Cloutier A, Khongorzul P, Raki AA, Gaudreau S, McDonald PP, Gris D, Amrani A.; PMED 36400308

17 (55) Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control Tat-activated transcription and latency ; Preprint 2023 ; Wilhelm E, Poirier M, Bedard M, McDonald PP, Lavigne P, Hunter C, Bell B

16 (54) CCR2-targeting pepducins reduce T cell-nociceptor interaction driving bone cancer pain ; Preprint 2023; Midavaine E, Brouillette RR, Theberge E, Mona CE, Kashem SW, Cote J, Zeugin V, Besserer-Offroy E, Longpre JM, Marsault E, Sarret P

15 (53) Gemcitabine promotes autophagy and lysosomal function through ERK-and TFEB-dependent mechanisms; Cell Death Discovery 2023; Marchand B, Poulin MA, Lawson C, Tai LH, Jean S, Boucher MJ ; PMED 36746928

14 (52) SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition ; Front. Immunol 2023 ; Limoges, M. A., Quenum, A. J. I., Chowdhury, M. M. H., Rexhepi, F., Namvarpour, M., Akbari, S. A., ... & Ramanathan, S; PMED 37809081

13 (51) Intratumoral administration of unconjugated Accum™ impairs the growth of pre-established solid lymphoma tumors ; JP Bikorimana, N El‐Hachem, M Moreau, C Lawson, LH Tai, M Gonçalves, J Abusarah; Cancer Science 2023; PMED 37776054

12 (50) The Immunomodulatory Effects of a 6-Month Extra Virgin Olive Oil Intervention on Monocyte Cytokine Secretion and Plasma Cytokine Levels in Dyslipidemic and Post-Infarct Patients: A Clinical Pilot Study ; A Zimmer, A Otrante, N Zoubdane, M Nguyen, T Fülöp, A Khalil; Nutrients ; 2023 ; PMED 37686851

11 (49) Acute Natural Killer Cells Response to a Continuous Moderate Intensity and a Work-Matched High Intensity Interval Exercise Session in Metastatic Cancer Patients Treated With Chemotherapy ; Preprint 2023; H Parent-Roberge, A Fontvieille, L Poirier, LH Tai, M Pavic, T Fülöp, E Riesco

10 (48) An improved method for isolation and flow cytometric characterization of intrahepatic leukocytes from fatty and fibrotic liver tissues ; R Kandhi, B Variya, S Ramanathan, S Ilangumaran; The Anatomical Record 2023; PMED 35848859

9 (47) Heterologous prime-boost cellular vaccination induces potent antitumor immunity against triple negative breast cancer ; SR Niavarani, G St-Cyr, L Daniel, C Lawson, H Giguère, AA Alkayyal, LH Tai ; Frontiers in immunology 2023; PMED 36860852

8 (46) Nlrc5-CIITA fusion protein as an effective inducer of MHC-I expression and antitumor immunity ; MA Santharam, A Shukla, D Levesque, TA Kufer, FM Boisvert, S Ramanathan; Int. J. Mol.Sci. 2023; PMED 37108368

7 (45) SARS-CoV-2 mRNA vaccine-induced immune responses in rheumatoid arthritis ; Limoges, M. A., Lortie, A., Demontier, É., Quenum, A. J. I., Lessard, F., Drouin, Z., ... & Roux, S; J. of Leukocyte Biology 2023; PMED 37478373

6 (44) Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis ; A Laniel, É Marouseau, DT Nguyen, U Froehlich, C McCartney, PL Boudreault, C Lavoie; Molecular Pharmaceutics 2023 ; PMED 36781165

5 (43) Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy ; Cancer Immunology Immunotherapy 2023; Rutihinda, C., Haroun, R., Saidi, N. E., Ordoñez, J. P., Naasri, S., Lévesque, D., ... & Oweida, A. J.; PMED 36326893

4 (42) IL-15 prevents the development of T-ALL from aberrant thymocytes with impaired DNA repair functions and increased NOTCH1 activation; Nandi, M., Ghosh, A., Akbari, S. A., Bobbala, D., Boucher, M. J., Menendez, A., ... & Ramanathan, S.; Cancers, 2023; PMED 36765626

3 (41) Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis ; Frontiers in Immunology 2023; R Kandhi, M Yeganeh, A Yoshimura, A Menendez, S Ramanathan, S Ilangumaran; PMED 37860002

2 (40) Characterization of the Cytotoxic T lymphocytes Acute Response Following Continuous Moderate Intensity and High Intensity Interval Exercise in Metastatic Cancer Patients Undergoing Chemotherapy ; H Parent-Roberge, A Fontvieille, L Poirier, LH Tai, M Pavic, T Fülöp, E Riesco; Preprint 2023

6 (38) Invadosome Formation by Lung Fibroblasts in Idiopathic Pulmonary Fibrosis ; Int. J. Mol. Sci. ; 2022 ; M Lebel, DO Cliche, M Charbonneau, D Adam, E Brochiero, CM Dubois, AM Cantin; PMED 36613948

5 (37) Human neutrophils generate extracellular vesicles that modulate their functional responses ; Cells 2022 ; MJ Hurtado Gutiérrez, FL Allard, HT Mosha, CM Dubois, PP McDonald; PMED 36611930

4 (36) Intravesical immunotherapy with a GM-CSF armed oncolytic vesicular stomatitis virus improves outcome in bladder cancer ; Mol Ther Oncolytics 2022 ; C Rangsitratkul, C Lawson, F Bernier-Godon, SR Niavarani, M Boudaud, S Rouleau, A-O. Gladu-Corbin, A. Surendran, N. Ekindi-Ndongo, M. Koti, C. S. Ilkow, P. O. Richard, L-H. Tai; PMED 35229029

3 (35) The Efficiency of Global Genome-Nucleotide Excision Repair is Linked to the Fraction of Open rRNA Gene Chromatin, in Yeast ; Photochemistry and Photobiology 2022; A Paillé, R Charton, Q Dholandre, A Conconi; PMED 34921417

2 (34) Dendritic cells and their immunotherapeutic potential for treating type 1 diabetes; Int. J. Mol. Sci. 2022; FU Khan, P Khongorzul, AA Raki, A Rajasekaran, D Gris, A Amrani; PMED 35563276

1 (33) Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes; Kidney360 2022; Lizotte F, Robillard S, Lavoie N, Rousseau M, Denhez B, Moreau J, Higgins S, Sabbagh R, Côté AM, Geraldes P; PMED 36514736

4 (32) Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease ; Immunity & Ageing 2021 ; U. Munawara, M. Catanzaro, W. Xu, C. Tan, K. Hirokawa, N. Bosco, D. Dumoulin, A. Khalil, A. Larbi, S. Lévesque, Ch. Ramassamy, A. E. Barron, St. Cunnane, P. B. Beauregard, J-P. Bellenger, S. Rodrigues, M. Desroches, J. M. Witkowski, B. Laurent, E. H. Frost & T. Fulop ; PMED 34154615

3 (31) IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes ; Front. Immunol 2021; M. Nandi, M. M. Moyo, S. Orkhis, J. M. F. Mobulakani, M-A. Limoges, F. Rexhepi, M. Mayhue, A. A. Cayarga, G. C. Marrero, S. Ilangumaran, A. Menendez, S. Ramanathan ; PMED 34956227

2 (30) Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene ; J. Biol. Chem 2021 ; M. Gagnon, M. Savard, J -F. Jacques, G. Bkaily, S. Geha, X. Roucou, F. Gobeil ; PMED 33497625

1 (29) Antioxidant Effect of Moroccan Pomegranate (Punica granatum L. Sefri Variety) Extracts Rich in Punicalagin against the Oxidative Stress Process ; Foods 2021 ; L. Benchagra, H. Berrougui, M. O. Islam, M. Ramchoun, S. Boulbaroud, A. Hajjaji, T. Fulop, G. Ferretti, A. Khalil ; PMED 34574329

3 (28) A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. Lacasse V, Beaudoin S, Jean S, Leyton JV. Mol Ther Methods Clin Dev. 2020 Sep 1

2 (27) Oncolytic vesicular stomatitis virus-based cellular vaccine improves triple-negative breast cancer outcome by enhancing natural killer and CD8+ T-cell functionality. Niavarani SR, Lawson C, Boudaud M, Simard C, Tai LH. J Immunother Cancer. 2020 Mar;8(1)

1 (26) Elucidating the Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b. Zerif E, Khan FU, Raki AA, Lullier V, Gris D, Dupuis G, Amrani A. Int J Mol Sci. 2020 Sep 4;21(18)

12 (25) Spore Germination Requires Ferrichrome Biosynthesis and the Siderophore Transporter Str1 in Schizosaccharomyces pombe; Genetics 2019; Samuel Plante 1, Simon Labbé; PMID 30647069

11 (24) Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells. Dubuc C, Savard M, Bovenzi V, Lessard A, Côté J, Neugebauer W, Geha S, Chemtob S, Gobeil F Jr. J Cell Physiol. 2019 Mar;234(3):2851-2865. doi: 10.1002/jcp.27103. Epub 2018 Aug 21. PMID: 30132865

10 (23) Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy. Beaulieu ME, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Serrano Del Pozo E, Fiore C, Foradada L, Cano VC, Sánchez-Hervás M, Guenther M, Romero Sanz E, Oteo M, Tremblay C, Martín G, Letourneau D, Montagne M, Morcillo Alonso MÁ, Whitfield JR, Lavigne P, Soucek L. Sci Transl Med. 2019 Mar 20;11(484)

9 (22) Proteomic-based evaluation of nuclear transport of NLS-tagged trastuzumab-emtansine with enhanced cytotoxic potency. Biology bioRxiv 2019; Vincent Lacasse, Simon Beaudoin, JV Leyton

8 (21) Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period. BMC Cancer. 2019; Niavarani SR, Lawson C, Bakos O, Boudaud M, Batenchuk C, Rouleau S, Tai LH.; PMID: 31429730

7 (20) Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B. Hamel-Côté G, Lapointe F, Gendron D, Rola-Pleszczynski M, Stankova J. Cell Commun Signal. 2019 Mar 4;17(1):21. doi: 10.1186/s12964-019-0334-6. PMID: 30832675

6 (19) Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D4-Induced CXCL8 Expression. Lapointe F, Turcotte S, Véronneau S, Rola-Pleszczynski M, Stankova J. J Pharmacol Exp Ther. 2019 May;369(2):270-281. doi: 10.1124/jpet.118.255422. PMID: 30867226

5 (18) NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLoS Biol. 2019; Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D; PMID: 31525189

4 (17) NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes. Mahmoud S, Gharagozloo M, Simard C, Amrani A, Gris D. Cells. 2019;. PMID: 31052241

3 (16) Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2. Cell Biosci. 2019; Hamel-Côté G, Lapointe F, Véronneau S, Mayhue M, Rola-Pleszczynski M, Stankova J; PMID: 31289638

2 (16) Analyses of rRNA gene chromatin in cell cycle arrested Saccharomyces cerevisiae cells. Data Brief. 2019; Paillé A, Charton R, Muguet A, Griesenbeck J, Smerdon MJ, Conconi A. PMID: 31294051

1 (15) In yeast cells arrested at the early S-phase by hydroxyurea, rRNA gene promoters and chromatin are poised for transcription while rRNA synthesis is compromised. Charton R, Muguet A, Griesenbeck J, Smerdon MJ, Conconi A. Mutat Res. 2019 May;815:20-29. PMID: 31063901

6 (14) Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue. Dianati V, Navals P, Couture F, Desjardins R, Dame A, Kwiatkowska A, Day R, Dory YL. J Med Chem. 2018 Dec 27;61(24):11250-11260

5 (13) Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines. Dianati V, Kwiatkowska A, Couture F, Desjardins R, Dory YL, Day R. J Med Chem. 2018 Sep 27;61(18):8457-8467. doi: 10.1021/acs.jmedchem.8b01144. Epub 2018 Sep 17. PMID: 30180568

4 (12) The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis. Gharagozloo M, Mahmoud S, Simard C, Mahvelati TM, Amrani A, Gris D Cells. 2018; 7: pii: E119 PMID: 30150571

3 (11) IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes. Boudaud M, Turcotte S, Stankova J, Rola-Pleszczynski M J Immunol. 2018; 201: 2787 PMID: 30242072

2 (10) Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells. Guindi C, Cloutier A, Gaudreau S, Zerif E, McDonald PP, Tatsiy O, Asselin C, Dupuis G, Gris D, Amrani AA. Cells. 2018 Dec 7;7(12). pii: E256. doi: 10.3390/cells7120256. PMID: 30544623

1 (9) Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer. Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F. Oncotarget. 2018 Jan 5;9(11):9885-9906. doi: 10.18632/oncotarget.24009. eCollection 2018 Feb 9. PMID: 29515778

8 (8) Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury. Theus MH, Brickler T, Meza AL, Coutermarsh-Ott S, Hazy A, Gris D, Allen IC J Immunol. 2017; 199: 3547 PMID: 28993512

7 (7) Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Paquette M, Vilera-Perez LG, Beaudoin S, Ekindi-Ndongo N, Boudreaut PL, Bonin MA, Battista MC, Bentourkia M, Lopez AF, Lecomte R, Marsault E, Guérin B, Sabbagh R, Leyton JV.Oncoimmunology. 2017; 19: 6: e1331195. PMID: 29123949

6 (6) Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. Ear T, Tatsiy O, Allard FL, McDonald PP J Immunol Res. 2017; 2017: 4347121 PMID: 28512645

5 (5) Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway.Hamel-Côté G, Gendron D, Rola-Pleszczynski M, Stankova J PLoS One. 2017; 12: e0180336 PMID: 28686728

4 (4) Modular sub-monomeric cell-penetrating guanidine-rich peptoids – synthesis, assembly and biological evaluation. E. Marouseau, A. Neckebroeck, H. Larkin, A. Le Roux, L. Volkov, C. L. Lavoie and E. Marsault RSC Adv. 2017; 7: 6059

3 (3) Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination. Plante S, Normant V, Ramos-Torres KM, Labbé SJ Biol Chem. 2017; 292: 11896 PMID: 28572514

2 (2) Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, Gris D, Stankova J, Rola-Pleszczynski M, Mourad W, Dupuis G, Amrani A. J Autoimmun. 2017; 76: 63 PMID: 27634616

1 (1) Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.Małuch I, Levesque C, Kwiatkowska A, Couture F, Ly K, Desjardins R, Neugebauer WA, Prahl A, Day R J Med Chem. 2017; 60: 2732 PMID: 28287731